(R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: (R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER
• CAS No.: 917572-30-6
• Molecular Formula: C14H19NO3
• Molecular Weight: 249.31
• Hs Code.: 2934999090
• Mol file: 917572-30-6.mol

Synonyms:(R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER;(R)-(4-Benzyl-morpholin-3-yl)-acetic acid methyl;(S)-(4-Benzylmorpholin-3-yl)aceticacidmethylester

Chemical Property of (R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000134mmHg at 25°C
• Boiling Point: 333.8°C at 760 mmHg
• Flash Point: 155.7°C
• PSA: 38.77000
• Density: 1.11g/cm³
• LogP: 1.38840

Purity/Quality:

99% ^*data from raw suppliers

(R)-Methyl2-(4-benzylmorpholin-3-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER

There total 3 articles about (R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + (R)-2-(4-benzylmorpholin-3-yl)acetonitrile (917572-29-3,1217855-96-3,170701-93-6) → methyl [(3R)-4-benzylmorpholin-3-yl]acetate (917572-30-6)

Guidance literature:

methanol; (R)-2-(4-benzylmorpholin-3-yl)acetonitrile; With hydrogenchloride; at 20 ℃;

With sodium carbonate; In water;

Reference yield:

(3R)-4-benzyl-3-(hydroxymethyl)-morpholine (101376-26-5) → methyl [(3R)-4-benzylmorpholin-3-yl]acetate (917572-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2.5 h / Heating / reflux

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / Heating / reflux

3: hydrogenchloride / 20 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; tetra(n-butyl)ammonium hydrogensulfate; N,N-dimethyl-formamide; In dichloromethane; water;

Reference yield:

(S)-4-benzyl-3-(chloromethyl)morpholine (917572-28-2) → methyl [(3R)-4-benzylmorpholin-3-yl]acetate (917572-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / Heating / reflux

2: hydrogenchloride / 20 °C

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water;

upstream raw materials:

methanol

(R)-2-(4-benzylmorpholin-3-yl)acetonitrile

(S)-4-benzyl-3-(chloromethyl)morpholine

(3R)-4-benzyl-3-(hydroxymethyl)-morpholine

Downstream raw materials:

2-[(3R)-4-benzylmorpholin-3-yl]ethanol

2-[(3R)-morpholin-3-yl]ethanol

2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol