methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Base Information

Chemical Name:methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate
CAS No.:1610371-76-0
Molecular Formula:C₂₂H₂₂ClF₃N₂O₂
Molecular Weight:438.877
Hs Code.:

Synonyms:methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Chemical Property of methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Technology Process of methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

There total 2 articles about methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1610371-74-8
methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

: 122488-73-7
1-(bromomethyl)-4-chloro-2-methylbenzene

: 1610371-76-0
methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: 1-(bromomethyl)-4-chloro-2-methylbenzene; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; at 65 ℃; for 1h; Inert atmosphere;

methyl 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1610371-24-8
2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610371-76-0
methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 40 °C

2.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 1 h / 65 °C / Inert atmosphere

2.2: 2 h / 80 °C / Inert atmosphere

With hydrogenchloride; chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran;

Reference yield: 65.0%

: 1610371-76-0
methyl 2-((4S,5S)-1-(4-(4-chloro-2-methylbenzyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1610371-77-1
methyl 2-((4S,5S)-1-(4-((3'-methoxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;