N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

Base Information

Chemical Name:N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide
CAS No.:1357168-30-9
Molecular Formula:C₂₄H₂₅N₃O₆S
Molecular Weight:483.545
Hs Code.:

Synonyms:N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

Chemical Property:

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Technology Process of N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

There total 7 articles about N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1021926-19-1
C₁₇H₂₂N₂O₃S

: 122-04-3
4-nitro-benzoyl chloride

: 1357168-30-9
N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

Guidance literature:: With potassium carbonate; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 930797-62-9
2-(2,5-dimethylbenzyloxy)-4-nitroaniline

: 1357168-30-9
N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: water; sodium hydroxide

3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: iron(III) chloride; water; zinc / N,N-dimethyl-formamide

5.1: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere

With iron(III) chloride; water; sodium hydride; potassium carbonate; sodium hydroxide; zinc; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.11.012

Reference yield:

: N-methyl-N-[2-(3',6'-dimethyl-benzyloxy)-4-nitrophenyl]-methanesulfonamide

: 1357168-30-9
N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron(III) chloride; water; zinc / N,N-dimethyl-formamide

2: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere

With iron(III) chloride; water; potassium carbonate; zinc; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.11.012