5-Methylpyrazolo[1,5-A]pyrimidin-7-OL

Base Information

• Chemical Name: 5-Methylpyrazolo[1,5-A]pyrimidin-7-OL
• CAS No.: 29274-35-9
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.152
• Hs Code.: 2933990090
• European Community (EC) Number: 863-588-5
• ChEMBL ID: CHEMBL4525057
• Mol file: 29274-35-9.mol

Synonyms:5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-OL;16082-26-1;29274-35-9;5-Methylpyrazolo[1,5-a]pyrimidin-7(4H)-one;5-methyl-4H,7H-pyrazolo[1,5-a]pyrimidin-7-one;5-methyl-1H-pyrazolo[1,5-a]pyrimidin-7-one;SCHEMBL4102510;SCHEMBL7711852;CHEMBL4525057;SCHEMBL12190827;MFCD00104730;AKOS006042774;AB03426;5-methylpyrazolo[1,5-a]pyrimidin-7-one;AM806390;TS-01954;CS-0080333;CS-0080370;FT-0692791;EN300-44232;D74153;AB00997136-01;J-017466;PYRAZOLO[1,5-A]PYRIMIDIN-7-OL, 5-METHYL-;5-METHYL-4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE;3,4-O-ISOPROPYLIDENE-L-THREONICACID,CALCIUMSALT;Z448099478

Chemical Property of 5-Methylpyrazolo[1,5-A]pyrimidin-7-OL

Chemical Property:

• PSA: 50.16000
• LogP: 0.33100
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 149.058911855
• Heavy Atom Count: 11
• Complexity: 301

Purity/Quality:

97% ^*data from raw suppliers

5-Methylpyrazolo[1,5-A]pyrimidin-7-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)N2C(=N1)C=CN2

Technology Process of 5-Methylpyrazolo[1,5-A]pyrimidin-7-OL

There total 5 articles about 5-Methylpyrazolo[1,5-A]pyrimidin-7-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl propanoyl acetate (30414-53-0) + 3(5)-aminopyrazole (1225387-53-0) → 5-methyl-4H-pyrazolo<1,5-a>pyrimidin-7-one (29274-35-9)

Guidance literature:

In acetic acid; at 90 ℃; for 16h;

DOI:10.1021/acs.jmedchem.1c00941

Reference yield: 87.0%

acetoacetic acid methyl ester (105-45-3) + 3(5)-aminopyrazole (1225387-53-0) → 5-methyl-4H-pyrazolo<1,5-a>pyrimidin-7-one (29274-35-9)

Guidance literature:

In acetic acid; at 120 ℃; for 16h; Reflux;

DOI:10.1016/j.bmc.2015.10.021

Reference yield: 87.0%

ethyl acetoacetate (141-97-9) + 3(5)-aminopyrazole (1225387-53-0) → 5-methyl-4H-pyrazolo<1,5-a>pyrimidin-7-one (29274-35-9)

Guidance literature:

With acetic acid; for 3h; Heating;

DOI:10.1248/cpb.47.928

upstream raw materials:

3-aminopyrazole

ethyl acetoacetate

3⁽⁵⁾-aminopyrazole

acetoacetic acid methyl ester

Downstream raw materials:

7-Oxo-4,5-dimethyl-4,7-dihydro-pyrazolo<1,5-a>pyrimidin

7-Chloro-5-methylpyrazolo[1,5-a]pyrimidine