N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

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Chemical Name:N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide
CAS No.:1384984-26-2
Molecular Formula:C₁₂H₉BrF₄N₂O₄
Molecular Weight:401.112
Hs Code.:

Synonyms:N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

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Chemical Property of N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

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Technology Process of N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

There total 4 articles about N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1384984-25-1
4-bromo-3-fluoro-2-(tetrahydrofuran-2-yl)aniline

: 407-25-0
trifluoroacetic anhydride

: 1384984-26-2
N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: 4-bromo-3-fluoro-2-(tetrahydrofuran-2-yl)aniline; trifluoroacetic anhydride; at 2 - 13 ℃; for 0.333333h;

With ammonium nitrate; In tetrahydrofuran; at 30 - 41 ℃; for 2.66667h;

Reference yield:

: 59255-94-6
2-bromo-3-fluoronitrobenzene

: 1384984-26-2
N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I) / 1,4-dioxane / 2 h / Reflux

1.2: 2327.23 Torr / Inert atmosphere

2.1: N-Bromosuccinimide / acetonitrile; tert-butyl methyl ether / 1 h / -20 - -10 °C

3.1: tetrahydrofuran / 2 - 35 °C

3.2: 2.67 h / 30 - 41 °C

With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); In tetrahydrofuran; 1,4-dioxane; tert-butyl methyl ether; acetonitrile; 1.1: Heck coupling;

Reference yield:

: 1384984-24-0
3-fluoro-2-(tetrahydrofuran-2-yl)aniline

: 1384984-26-2
N-(4-bromo-3-fluoro-6-nitro-2-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: aniline; N-Bromosuccinimide; sodium thiosulfate / ethyl acetate; hexane; tert-butyl methyl ether

2: trifluoroacetic anhydride; NH₄NO₃ / tetrahydrofuran

With N-Bromosuccinimide; NH₄NO₃; sodium thiosulfate; aniline; trifluoroacetic anhydride; In tetrahydrofuran; hexane; tert-butyl methyl ether; ethyl acetate;