(S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

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Chemical Name:(S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid
CAS No.:1033804-83-9
Molecular Formula:C₂₇H₂₁F₃N₆O₃
Molecular Weight:534.497
Hs Code.:

Synonyms:(S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

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Chemical Property of (S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

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Technology Process of (S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

There total 5 articles about (S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033804-87-3
(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

: 1033804-83-9
(S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1033804-83-9
(S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.17 h / 100 °C / Microwave irradiation; Sealed tube

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

2.2: 20 °C

3.1: caesium carbonate / 1,4-dioxane / 110 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium carbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 741709-63-7
2-cyanopyridine-5-boronic acid pinacol ester

: 1033804-83-9
(S)-2-amino-3-[4-(2-amino-6-{1-[2-(6-cyano-pyridin-3-yl)-phenyl]-2,2,2-tri-fluoro-ethoxy}-pyrimidin-4-yl)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.17 h / 100 °C / Microwave irradiation; Sealed tube

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

2.2: 20 °C

3.1: caesium carbonate / 1,4-dioxane / 110 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium carbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;