(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

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Chemical Name:(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid
CAS No.:1033804-87-3
Molecular Formula:C₃₂H₂₉F₃N₆O₅
Molecular Weight:634.615
Hs Code.:

Synonyms:(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

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Chemical Property of (S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

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Technology Process of (S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

There total 4 articles about (S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1033804-85-1
5-[2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]pyridine-2-carbonitrile

: 1033804-86-2
(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

: 1033804-87-3
(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

Guidance literature:: 5-[2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]pyridine-2-carbonitrile; (S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid; With caesium carbonate; In 1,4-dioxane; at 110 ℃;

With hydrogenchloride; water; In 1,4-dioxane; pH=4.5;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1033804-87-3
(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.17 h / 100 °C / Microwave irradiation; Sealed tube

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

2.2: 20 °C

3.1: caesium carbonate / 1,4-dioxane / 110 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 741709-63-7
2-cyanopyridine-5-boronic acid pinacol ester

: 1033804-87-3
(S)-3-[4-(2-amino-6-{1-[2-(6-cyanopyridin-3-yl)phenyl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)phenyl]-2-tert-butoxycarbonylaminopropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.17 h / 100 °C / Microwave irradiation; Sealed tube

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

2.2: 20 °C

3.1: caesium carbonate / 1,4-dioxane / 110 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;