ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

Base Information

Chemical Name:ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate
CAS No.:1265323-56-5
Molecular Formula:C₁₈H₂₄N₂O₃
Molecular Weight:316.4
Hs Code.:

Synonyms:ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

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Chemical Property of ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

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Technology Process of ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

There total 7 articles about ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 16780-05-5
(S)-ethyl 2-(piperidin-3-yl)acetate hydrochloride

: 179694-33-8
(S)-(+)-2-(4-cyanophenyl)oxirane

: 1265323-56-5
ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

Guidance literature:: (S)-ethyl 2-(piperidin-3-yl)acetate hydrochloride; With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 35 ℃; for 0.333333h; Inert atmosphere;

(S)-(+)-2-(4-cyanophenyl)oxirane; In isopropyl alcohol; at 50 ℃; for 6h;

With dmap; In isopropyl alcohol; at 50 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1265323-55-4
(R)-ethyl 2-(1-(2-(4-cyanophenyl)-2-oxoethyl)piperidin-3-yl)acetate

: 1265323-56-5
ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

: 1265323-57-6
ethyl 2-((R)-1-((R)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

Guidance literature:: (R)-ethyl 2-(1-(2-(4-cyanophenyl)-2-oxoethyl)piperidin-3-yl)acetate; With sodium tetrahydroborate; In methanol; for 1h;

With water; In methanol;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1265323-56-5
ethyl 2-((R)-1-((S)-2-(4-cyanophenyl)-2-hydroxyethyl)-piperidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: D-glucose; nicotinamide adenine dinucleotide / dimethyl sulfoxide / 0.5 h / Sodium phosphate buffer

1.2: 6 h / pH 5.5 - 6

2.1: sodium t-butanolate / 1.5 h

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 35 °C / Inert atmosphere

3.2: 6 h / 50 °C

3.3: 12 h / 50 °C / Inert atmosphere

With D-glucose; nicotinamide adenine dinucleotide; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In dimethyl sulfoxide; isopropyl alcohol;