5-Methoxypyridine-3,4-diamine

Base Information

• Chemical Name: 5-Methoxypyridine-3,4-diamine
• CAS No.: 127356-27-8
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.157
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10563737
• Wikidata: Q82448216
• Mol file: 127356-27-8.mol

Synonyms:5-Methoxypyridine-3,4-diamine;127356-27-8;5-METHOXY-PYRIDINE-3,4-DIAMINE;3,4-Pyridinediamine,5-methoxy-(9CI);3,4-Diamino-5-methoxypyridine;SCHEMBL2953394;DTXSID10563737;AKOS006341790;SB32606;W-205280

Chemical Property of 5-Methoxypyridine-3,4-diamine

Chemical Property:

• Boiling Point: 383.0±37.0 °C(Predicted)
• PKA: 9.13±0.10(Predicted)
• PSA: 74.16000
• Density: 1.251±0.06 g/cm3(Predicted)
• LogP: 1.41700
• Storage Temp.: 2-8°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 139.074561919
• Heavy Atom Count: 10
• Complexity: 109

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-pyridine-3,4-diamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CN=C1)N)N

Technology Process of 5-Methoxypyridine-3,4-diamine

There total 4 articles about 5-Methoxypyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-amino-3-methoxy-5-nitropyridine (127356-39-2) → 3,4-diamino-5-methoxypyridine (127356-27-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield:

4-amino-3-methoxy pyridine (52334-90-4) → 3,4-diamino-5-methoxypyridine (127356-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / conc. H₂SO₄, HNO₃ / 3 h / 0 - 60 °C

2: 85 percent / H₂ / 10percent Pd/C / methanol

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00170a030

Reference yield:

3-methoxy-4-nitropyridine 1-oxide (19355-04-5) → 3,4-diamino-5-methoxypyridine (127356-27-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / H₂ / Raney Ni / methanol / 2.5 h / 40 °C / 30400 Torr

2: 37 percent / conc. H₂SO₄, HNO₃ / 3 h / 0 - 60 °C

3: 85 percent / H₂ / 10percent Pd/C / methanol

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; nickel; In methanol;

DOI:10.1021/jm00170a030

upstream raw materials:

4-amino-3-methoxy-5-nitropyridine

4-amino-3-methoxy pyridine

3-methoxy-4-nitropyridine 1-oxide

Downstream raw materials:

2-(4-Methanesulfinyl-2-methoxy-phenyl)-7-methoxy-1H-imidazo[4,5-c]pyridine

7-Methoxy-2-(2-methoxy-4-methylsulfanyl-phenyl)-1H-imidazo[4,5-c]pyridine

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