19355-04-5Relevant academic research and scientific papers
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
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Page/Page column 125, (2022/01/24)
The present invention relates to chemical entities (for example, a pharmaceutically acceptable compound or salt, and / or a hydrate, and / or a co-crystal, and / or a combination of drug of the compound) which inhibit (for example, antagonize) the stimula
Heterocyclic compound used as MNK inhibitor
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, (2019/01/08)
The invention relates to a heterocyclic compound, a pharmaceutical composition containing the heterocyclic compound, a preparation method thereof, and application thereof used as a mitogen activated protein kinase interacting kinase 1 and 2-MNK1/MNK2 inhibitor. The inhibitor is the heterocyclic compound as shown in the formula (I), or its pharmaceutically acceptable salt, prodrug, solvent compound, polycrystal, isomer, stable isotope derivative or a pharmaceutical composition containing the heterocyclic compound. The compound of the invention can be used for treating or preventing MNK-mediatedrelated diseases, such as cancers.
PEST CONTROL AGENT
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Paragraph 0136, (2016/10/09)
PROBLEM TO BE SOLVED: To provide a compound having high activity to pest, a pest control agent obtained using the compound and a method for controlling pest by application of the compound. SOLUTION: The present invention provides the pest control agent co
SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1
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, (2016/04/26)
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
PEST CONTROL AGENT
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Page/Page column 40, (2014/07/08)
Objects of the present invention are to provide a compound which is highly active against pests, to provide a pest control agent comprising the compound, and to provide a method for controlling a pest by applying the compound. The present invention provid
Hydrogen bonding-mediated self-assembly of square and triangular metallocyclophanes
Wu, Zong-Quan,Jiang, Xi-Kui,Li, Zhan-Ting
, p. 8067 - 8070 (2007/10/03)
Intramolecular three-centered hydrogen bonding has been used to induce dipyridyl anthranilamide 5 and diphenylacetylene anthranilamide 11 to adopt rigid straight conformation. Compound 5 reacted with Pd(dppp)(OTf)2 (12a) or Pt(dppp)(OTf)2 (12b) in dichloromethane to afford square metallocyclophanes 13a and 13b in 70% and 40% yield, respectively. In contrast, the reaction of 11 with 12b in dichloromethane gave triangular metallocyclophane 14 in 15% yield.
A USEFUL CONSTRUCTION OF 4-SUBSTITUTED 1-ALKYLPIPERID-3-ONES
Swindell, Charles S.,Duffy, Ruth H.
, p. 3373 - 3377 (2007/10/02)
A potentially general construction of 4-substituted 1-alkylpiperid-3-ones is described which employs 3-methoxy-4-bromopyridine as the crucial reagent.This substance is coupled at C-4 with Grignard reagents through the Kumada reaction.The resulting pyridines are then N-alkylated and subsequently subjected to borohydride reduction and aqueous acidic hydrolysis to reveal the title piperidones and related substances.
