52334-90-4

Usage

Uses

3-Methoxy-4-pyridinamine, is a building block used in various chemical synthesis.

InChI:InChI=1/C6H8N2O/c1-9-6-4-8-3-2-5(6)7/h2-4H,1H3,(H2,7,8)

Upstream product

• 7295-76-3 3-methoxypyridine 
• 1336-21-6 ammonium hydroxide 
• 19355-04-5 3-methoxy-4-nitropyridine 1-oxide 
• 75-09-2 dichloromethane 
• 14906-61-7 3-methoxypyridine N-oxide 

Downstream Products

• 1620292-59-2 phenyl (3-methoxypyridin-4-yl)carbamate 
• 1303557-53-0 [2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-(3-methoxy-pyridin-4-yl)-amine 
• 52334-53-9 4-amino-3-hydroxy pyridine 
• 127356-09-6 2-(4-Methanesulfinyl-2-methoxy-phenyl)-7-methoxy-1H-imidazo[4,5-c]pyridine 
• 127356-31-4 7-Methoxy-2-(2-methoxy-4-methylsulfanyl-phenyl)-1H-imidazo[4,5-c]pyridine 
• 127356-27-8 3,4-diamino-5-methoxypyridine 
• 127356-39-2 4-amino-3-methoxy-5-nitropyridine 

Relevant academic research and scientific papers

Heterocyclic compound used as MNK inhibitor

The invention relates to a heterocyclic compound, a pharmaceutical composition containing the heterocyclic compound, a preparation method thereof, and application thereof used as a mitogen activated protein kinase interacting kinase 1 and 2-MNK1/MNK2 inhibitor. The inhibitor is the heterocyclic compound as shown in the formula (I), or its pharmaceutically acceptable salt, prodrug, solvent compound, polycrystal, isomer, stable isotope derivative or a pharmaceutical composition containing the heterocyclic compound. The compound of the invention can be used for treating or preventing MNK-mediatedrelated diseases, such as cancers.

Hydrogen bonding-mediated self-assembly of square and triangular metallocyclophanes

Intramolecular three-centered hydrogen bonding has been used to induce dipyridyl anthranilamide 5 and diphenylacetylene anthranilamide 11 to adopt rigid straight conformation. Compound 5 reacted with Pd(dppp)(OTf)2 (12a) or Pt(dppp)(OTf)2 (12b) in dichloromethane to afford square metallocyclophanes 13a and 13b in 70% and 40% yield, respectively. In contrast, the reaction of 11 with 12b in dichloromethane gave triangular metallocyclophane 14 in 15% yield.

Inotropic 'A' ring substituted sulmazole and isomazole analogues

A series of 'A' ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pK(A)'s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated. No simple correlation between inotropic activity and pK(A), protonation site, or log P value was observed. However, in vitro inotropism did correlate with the calculated charge density of the 'B' ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, th 6-amino derivative 7 being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole 13 had comparable in vivo inotropic properties to those of isomazole.