1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

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Chemical Name:1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile
CAS No.:1361224-21-6
Molecular Formula:C₂₃H₂₇F₃N₄O₃S₂
Molecular Weight:528.62
Hs Code.:

Synonyms:1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

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Chemical Property of 1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

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Technology Process of 1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

There total 6 articles about 1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1191-95-3
cyclobutanone

: 7677-24-9
trimethylsilyl cyanide

: 1361222-59-4
2-(4-((2S)-2-(aminomethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol

: 1361224-21-6
1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

Guidance literature:: cyclobutanone; 2-(4-((2S)-2-(aminomethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-1,1,1-trifluoro-2-propanol; In 1,2-dichloro-ethane; at 20 ℃; for 0.333333h;

trimethylsilyl cyanide; In 1,2-dichloro-ethane; at 20 ℃; for 12h;

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 1361224-21-6
1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 12 h / 65 °C / sealed vessel; Inert atmosphere

3.1: boron trichloride / dichloromethane / 0.67 h / 0 °C

4.1: triethylamine / dichloromethane / 0 °C

5.1: ammonia / methanol / 0.5 h / 140 °C / sealed vial; microwave irradiation

6.1: 1,2-dichloro-ethane / 0.33 h / 20 °C

6.2: 12 h / 20 °C

With n-butyllithium; ammonia; boron trichloride; triethylamine; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In methanol; hexanes; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 122243-28-1
2‐(4‐bromophenyl)‐1,1,1‐trifluoropropan‐2‐ol

: 1361224-21-6
1-((((2S)-4-(2-thiophenylsulfonyl)-1-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)phenyl)-2-piperazinyl)methyl)amino)cyclobutanecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 12 h / 65 °C / sealed vessel; Inert atmosphere

2.1: boron trichloride / dichloromethane / 0.67 h / 0 °C

3.1: triethylamine / dichloromethane / 0 °C

4.1: ammonia / methanol / 0.5 h / 140 °C / sealed vial; microwave irradiation

5.1: 1,2-dichloro-ethane / 0.33 h / 20 °C

5.2: 12 h / 20 °C

With ammonia; boron trichloride; triethylamine; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In methanol; dichloromethane; 1,2-dichloro-ethane; toluene;