(1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Base Information

Chemical Name:(1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol
CAS No.:147213-96-5
Molecular Formula:C₁₇H₂₈Cl₂O₄SSi
Molecular Weight:427.464
Hs Code.:

Synonyms:(1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Suppliers and Price of (1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

There total 4 articles about (1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 124-63-0
methanesulfonyl chloride

: 147189-95-5
(1R)-(3,4-Dichlorophenyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-butanol

: 147213-96-5
(1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 50597-19-8
3-(3,4-dichlorobenzoyl)-propionic acid

: 147213-96-5
(1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄, 1N aq. NaOH / 18 h / Ambient temperature

2: 10.33 g / LiAlH₄ / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C

3: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t.

4: 97 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 118528-87-3
4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid

: 147213-96-5
(1R)-(3,4-Dichlorophenyl)-α-<3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>propyl>methanesulfonate benzenemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 10.33 g / LiAlH₄ / tetrahydrofuran / 1) 1 h, ice-bath, 2) 1 h, 25 deg C, 3) 1.5 h, 60 deg C

2: 98 percent / imidazole / dimethylformamide / 18 h / ice-bath temp. to r.t.

3: 97 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88330-7