Technology Process of (1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-(2-oxo-2-phenylethoxy)benzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate
There total 17 articles about (1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-(2-oxo-2-phenylethoxy)benzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid; hydrogen bromide; bromine / 2 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
With
hydrogen bromide; bromine; acetic acid; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium ethanolate / ethanol / 55 °C / Inert atmosphere
2: trifluoroacetic acid; sodium hydrogencarbonate / dichloromethane / 0 - 20 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
4: acetic acid; hydrogen bromide / 3 h / 20 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
With
dmap; tetrakis(triphenylphosphine) palladium(0); hydrogen bromide; sodium ethanolate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;