(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Base Information

Chemical Name:(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide
CAS No.:1252637-07-2
Molecular Formula:C₂₃H₂₃F₆N₃O₅S
Molecular Weight:567.509
Hs Code.:

(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Synonyms:(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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Chemical Property of (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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Technology Process of (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

There total 16 articles about (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

: 1434818-39-9
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

: 1252637-07-2
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: With Monoperoxyphthalic acid, magnesium salt; In methanol; at 50 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time;

Reference yield: 73.0%

: 1252637-07-2
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:

Reference yield:

: 6914-76-7
1-Methyl-cyclopropanoic acid

: 1252637-07-2
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 2 h / -40 - 40 °C

2.1: triethylamine; dmap / dichloromethane / 2.5 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium hydroxide / 1 h / 0 - 20 °C

3.2: 21 h / 70 °C

4.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C

5.2: 15 h / 20 °C

6.1: Monoperoxyphthalic acid, magnesium salt / methanol / 24 h / 50 °C

With dmap; thionyl chloride; potassium tert-butylate; Monoperoxyphthalic acid, magnesium salt; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;