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(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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  • Chemical Name:(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide
  • CAS No.:1434818-39-9
  • Molecular Formula:C23H23F6N3O3S
  • Molecular Weight:535.51
  • Hs Code.:
  • Mol file:1434818-39-9.mol
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

Synonyms:(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

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Chemical Property of (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide Edit
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Technology Process of (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

There total 13 articles about (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenethiol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.333333h;
benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 15h; Reagent/catalyst; Solvent; Time; Temperature;
Guidance literature:
Multi-step reaction with 4 steps
1.1: triethylamine / N,N-dimethyl-formamide; dichloromethane / 1.17 h / 2 - 20 °C
2.1: sodium 2-ethylhexanoic acid / water / 16 h / 50 °C
2.2: 20 °C
3.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C
4.2: 15 h / 20 °C
With dmap; potassium tert-butylate; triethylamine; sodium 2-ethylhexanoic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
Guidance literature:
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / 2 h / -40 - 40 °C
2.1: triethylamine; dmap / dichloromethane / 2.5 h / 0 °C
2.2: 1.5 h / 0 °C
3.1: sodium hydroxide / 1 h / 0 - 20 °C
3.2: 21 h / 70 °C
4.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 20 °C
5.2: 15 h / 20 °C
With dmap; thionyl chloride; potassium tert-butylate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane;
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