chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle

Base Information

• Chemical Name: chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle
• CAS No.: 711-47-7
• Molecular Formula: C₉H₉ClO₄
• Molecular Weight: 216.621
• Mol file: 711-47-7.mol

Synonyms:chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle

Chemical Property of chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle

There total 6 articles about chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl orsellinate (3187-58-4) → chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle (711-47-7) + methyl 3,5-dichloro-2,4-dihydroxy-6-methylbenzoate (715-34-4)

Guidance literature:

With sulfuryl dichloride; In diethyl ether; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2010.04.024

Reference yield: 79.0%

methanol (67-56-1) + 3-chloro-4,6-dihydroxy-2-methylbenzoic acid (30448-89-6) → chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle (711-47-7)

Guidance literature:

methanol; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 ℃; for 1h; Inert atmosphere;

3-chloro-4,6-dihydroxy-2-methylbenzoic acid; In tetrahydrofuran; toluene; at 0 ℃; for 1.5h;

Reference yield:

3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde (83324-59-8) → chloro-3-dihydroxy-4,6-methyl-2-benzoate de methyle (711-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0.08 h / 0 °C

1.2: 15 h / 0 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 0 °C

With sodium dihydrogenphosphate dihydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; dimethyl sulfoxide; toluene;

upstream raw materials:

methyl orsellinate

3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde

methanol

3-chloro-4,6-dihydroxy-2-methylbenzoic acid

Downstream raw materials:

bis(benzyloxy)-4,6-chloro-3-methyl-2-benzoate de methyle

chloro-3-hydroxy-6-methoxy-4-methyl-2-benzoate de methyle

acide bis(benzyloxy)-4,6-chloro-3-methyl-2-benzoique

2-chloro-5-hydroxy-3-methoxytoluene