6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS No.:1430330-10-1
Molecular Formula:C₃₁H₃₄N₆O₃S
Molecular Weight:570.715
Hs Code.:

Synonyms:6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Chemical Property of 6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Technology Process of 6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 9 articles about 6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421253-74-8
1-(4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

: 60-34-4
methylhydrazine

: 1430330-10-1
6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 120 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

Reference yield:

: 1421067-10-8
6-benzyl-2-chloro-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1430330-10-1
6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 1.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water; tetrahydrofuran / 1.5 h

3: dmap / toluene / 0.58 h / 150 °C / Microwave irradiation; Sealed tube

4: Lawessons reagent / tetrahydrofuran / 0.17 h / 120 °C / Microwave irradiation; Sealed tube

With Lawessons reagent; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; sodium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 778574-06-4
6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

: 1430330-10-1
6-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 0.75 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 1.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water; tetrahydrofuran / 1.5 h

4: dmap / toluene / 0.58 h / 150 °C / Microwave irradiation; Sealed tube

5: Lawessons reagent / tetrahydrofuran / 0.17 h / 120 °C / Microwave irradiation; Sealed tube

With Lawessons reagent; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; sodium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;