1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

Base Information

Chemical Name:1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole
CAS No.:1442445-43-3
Molecular Formula:C₂₁H₂₂ClF₃N₄
Molecular Weight:422.881
Hs Code.:

Synonyms:1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

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Chemical Property of 1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

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Technology Process of 1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

There total 6 articles about 1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1442445-42-2
(R)-6-bromo-1-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d]imidazole

: 74879-18-8
(S)-2-methylpiperazine

: 1442445-43-3
1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 320-43-4
4-chloro-2-(trifluoromethyl)benzaldehyde

: 1442445-43-3
1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / dichloromethane / 48 h / 20 °C

2: dichloromethane; diethyl ether / 18 h / -48 °C

3: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C

4: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

5: iron / 1 h / 100 °C

6: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1442445-19-3
(S)-N-(4-chloro-2-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

: 1442445-43-3
1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-((R)-3-methylpiperazin-1-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; diethyl ether / 18 h / -48 °C

2: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C

3: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

4: iron / 1 h / 100 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;