(S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide
• CAS No.: 1442445-20-6
• Molecular Formula: C₁₃H₁₇ClF₃NOS
• Molecular Weight: 327.798

Synonyms:(S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Chemical Property of (S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

There total 2 articles about (S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(4-chloro-2-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide (1442445-19-3) + methylmagnesium bromide (75-16-1) → (S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (1442445-20-6)

Guidance literature:

In diethyl ether; dichloromethane; at -48 ℃; for 18h;

Reference yield:

4-chloro-2-(trifluoromethyl)benzaldehyde (320-43-4) → (S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (1442445-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) tetraethanolate / dichloromethane / 48 h / 20 °C

2: dichloromethane; diethyl ether / 18 h / -48 °C

With titanium(IV) tetraethanolate; In diethyl ether; dichloromethane;

Reference yield:

(S)-N-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (1442445-20-6) → (1R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethanamine (1389354-24-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h;

upstream raw materials:

4-chloro-2-(trifluoromethyl)benzaldehyde

(S)-N-(4-chloro-2-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

methylmagnesium bromide

Downstream raw materials:

(R)-5-bromo-N-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)benzene-1,2-diamine

(R)-6-bromo-1-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazole

(R)-tert-butyl 4-(1-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridine-1(2H)-carboxylate

(R)-1-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]triazole

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