Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin

Base Information

• Chemical Name: Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin
• CAS No.: 18678-98-3
• Molecular Formula: C₃₁H₅₈NO₆P
• Molecular Weight: 571.778
• Mol file: 18678-98-3.mol

Synonyms:Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin

Chemical Property of Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin

There total 23 articles about Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyloxy-3-hexadecyloxy-1-propanol (18678-94-9) → Rac. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin (18678-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / CHCl₃ / Ambient temperature

2: acetonitrile; CHCl₃ / Ambient temperature

With triethylamine; In chloroform; acetonitrile;

DOI:10.1016/0009-3084(94)02405-T

Reference yield:

1-O-hexadecyl-3-O-trityl-rac-glycerol (82002-20-8) → Rac. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin (18678-98-3)

Guidance literature:

Multi-step reaction with 4 steps

1: t-BuOK / 2-methyl-propan-2-ol / 70 °C

2: BF₃*MeOH / CH₂Cl₂ / Ambient temperature

3: NEt₃ / CHCl₃ / Ambient temperature

4: acetonitrile; CHCl₃ / Ambient temperature

With potassium tert-butylate; boron trifluoride methanol complex; triethylamine; In dichloromethane; chloroform; acetonitrile; tert-butyl alcohol;

DOI:10.1016/0009-3084(94)02405-T

Reference yield:

2-O-Benzyl-1-O-hexadecyl-3-O-trityl-glycerin (82002-21-9) → Rac. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin (18678-98-3)

Guidance literature:

Multi-step reaction with 3 steps

1: BF₃*MeOH / CH₂Cl₂ / Ambient temperature

2: NEt₃ / CHCl₃ / Ambient temperature

3: acetonitrile; CHCl₃ / Ambient temperature

With boron trifluoride methanol complex; triethylamine; In dichloromethane; chloroform; acetonitrile;

DOI:10.1016/0009-3084(94)02405-T

upstream raw materials:

2-bromoethylphosphoric acid dichloride

2-benzyloxy-3-hexadecyloxy-1-propanol

trimethylamine

choline tosylate

Downstream raw materials:

3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine

2-hydroxy-3-(hexadecyloxy)-propyl 2-trimethylammonioethyl phosphate

Refernces

• 1、 Rattay, Bernd,Brezesinski, Gerald,Dobner, Bodo,Foerster, Guenter,Nuhn, Peter. "Influence of α-branched fatty acid chains on the thermotropic behaviour of racemic 1-O-hexadecyl-2-acyl-glycero-3-phosphocholines". . p. 81 - 92. Retrieved 2007/10/02.
• 2、 Godfroid, Jean-Jacques,Broquet, Colette,Jouquey, Simone,Lebbar, Mariya,Heymans, Francoise,et al.. "Structure-Activity Relationship in PAF-acether. 3. Hydrophobic Contribution to Agonistic Activity". . p. 792 - 797. Retrieved 2007/10/02.