2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester

Base Information

• Chemical Name: 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester
• CAS No.: 125422-65-3
• Molecular Formula: C₁₈H₂₁NO₇
• Molecular Weight: 363.367
• Mol file: 125422-65-3.mol

Synonyms:2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester

Chemical Property of 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester

There total 2 articles about 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-ethoxy-2-phenyl-1,3-oxazole (25755-93-5) + Diethyl ketomalonate (609-09-6) → 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester (125422-65-3)

Guidance literature:

With tin(IV) chloride; In acetonitrile; for 19h; Ambient temperature;

DOI:10.1246/cl.1994.1673

Reference yield:

5-ethoxy-2-phenyl-1,3-oxazole (25755-93-5) + Diethyl ketomalonate (609-09-6) → 2,5,5-tricarbethoxy-4-phenyl-3-oxazoline (125422-64-2) + 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester (125422-65-3)

Guidance literature:

In xylene; for 46h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1016/S0040-4020(01)81032-2

upstream raw materials:

5-ethoxy-2-phenyl-1,3-oxazole

Diethyl ketomalonate