25755-93-5

Upstream product

• 1499-53-2 ethyl hippurate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 98-88-4 benzoyl chloride 
• 23893-63-2 ethyl 3-phenyl-2H-azirine-2-carboxylate 
• 623-73-4 diazoacetic acid ethyl ester 
• 100-47-0 benzonitrile 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 10026-13-8 phosphorus pentachloride 
• 284040-82-0 5-Ethoxy-2-phenyl-4-triethylsilyloxazole 
• 180901-65-9 {[1-Chloro-1-phenyl-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 
• 637-81-0 ethyl-2-azidoacetate 
• 618-32-6 Benzoyl bromide 

Downstream Products

• 125422-61-9 2,5-diphenyl-7-carbethoxy-2,4,6,8-tetraaza <3.3.1>bicyclooct-5-ene-1,3-dione 
• 125422-53-9 1,2,5-tricarbethoxy-3-phenyl-Δ³-1,2,4-triazoline 
• 4971-80-6 ethyl N-benzoylcarbamate 
• 125422-55-1 (1R,7aS)-6-(4-Chloro-phenyl)-5,7-dioxo-3-phenyl-5,6,7,7a-tetrahydro-1H-imidazo[1,5-c]imidazole-1-carboxylic acid ethyl ester 
• 125422-55-1 (1S,7aS)-6-(4-Chloro-phenyl)-5,7-dioxo-3-phenyl-5,6,7,7a-tetrahydro-1H-imidazo[1,5-c]imidazole-1-carboxylic acid ethyl ester 
• 125422-57-3 2-phenyl-4-(dicarbethoxyhydroxymethyl)-5-ethoxy-oxazole 
• 125422-64-2 2,5,5-tricarbethoxy-4-phenyl-3-oxazoline 
• 125422-65-3 2-phenyl-4,5-dihydro-1,3-oxazole-4,5,5-tricarboxylic acid triethyl ester 
• 495-69-2 Hippuric Acid 
• 64-17-5 ethanol 
• 56-40-6 glycine 
• 65-85-0 benzoic acid 
• 125422-60-8 1,2,-dicarbethoxy-3-phenyl-5-carbmethoxy-Δ³-1,2,4-triazoline 

Relevant academic research and scientific papers

Mechanistic understanding of a silver pyridylpyrrolide as a catalyst for 3 + 2 cyclization of a nitrile with diazo ester

The trinuclear argentate complex Ag3(μ2-3,5- (CF3)2PyrPy)3 (PyrPy = 2,2′- pyridylpyrrolide) catalyzes the 3 + 2 cycloaddition of several NCR (R = Me, Ph, tBu) and N2CHCO2Et to disubstituted oxazoles, even in the presence of light and air. Structural and theoretical studies imply a three-coordinate silver carbene complex, (3,5-(CF3) 2PyrPy)Ag(CHCO2Et), to be responsible in a stepwise nitrile addition and cyclization step to form the heterocycle.

Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs

Our aim was to identify new multi-target compounds endowed with both anti-inflammatory and anti-bacterial activities for treatment of human infections. Diflunisal, a nonsteroidal anti-inflammatory agent, has recently been repurposed for its anti-virulence properties against methicillin-resistant Staphylococcus aureus. Effective synthesis of some aza-analogs of the anti-inflammatory drug diflunisal was carried out following the route involving key oxazole intermediates to obtain o- and m-hydroxypyridinecarboxylic acid derivatives. The newly synthesized diflunisal aza-analogs did not exhibit cytotoxic activity up to 80 μM and some of them exhibited anti-inflammatory activities, decreasing the levels of pro-inflammatory cytokines and prostaglandins induced by bacterial lipopolysaccharide in human primary macrophages. Ten of the diflunisal aza-analogs were found to have interesting antibacterial activity, sensitizing S. aureus, Streptococcus pyogenes, Enterococcus faecium, and Pseudomonas aeruginosa to the antibacterial effects of beta-lactam antibiotics and protein synthesis inhibitors.

Copper-Catalyzed Aerobic Oxidative [2 + 3] Cyclization/Aromatization Cascade Reaction: Atom-Economical Access to Tetrasubstituted 4,5-Biscarbonyl Imidazoles

An atom-economical method for accessing tetrasubstituted 4,5-biscarbonylimidazoles by reaction between glycine derivatives and 5-alkoxyoxazoles is reported. The method, which involves a copper-catalyzed aerobic oxidative [2 + 3] cyclization/aromatization

Copper-exchanged bentonite: A reusable catalysis for the formation of alkoxycarbonyl nitrile ylides under microwave irradiation

Ethyldiazoacetate reacts as a carbene precursor in presence of copper exchanged bentonite. Reaction with excess nitrile gave oxazole derivatives. Their formation is explained by intramolecular 1,5-cyclisation of alkoxycarbonyl substituted nitrile ylide intermediate.

Synthesis and reactivity of 4-silylated oxazoles

Treatment of (triethylsilyl)diazoacetates with rhodium(II) octanoate and a range of substituted nitriles generates trisubstituted oxazoles bearing a triethylsilyl group in the 4-position. Fluoride-mediated desilylation yields 3,5-disubstituted oxazoles, w

Regiospecific syntheses of the monomethylated 3-phenyldihydro-1,2,4-triazin-6(1H)-ones

Unambiguous syntheses of four unreported monomethylated derivatives of 3-phenyldiliydro-1,2,4-triazin-6(1H)-ones, namely, the 1-methyl (2), 2-methyl (3), 4-methyl (4) and the imidic O-methyl derivative (5), are described. Regioselectivity was achieved for

Formation of Acyl-Substituted Nitrile Ylides by Rh2(OAc)4-Catalyzed Decomposition of α-Diazocarbonyl Compounds in Nitriles

The Rh2(OAc)4-catalyzed reactions of α-diazocarbonyl compounds in nitrile in the presence of dimethyl acetylenedicarboxylate (DMAD) gave oxazole and pyrrole derivatives.The formation of the oxazole derivatives is explained in terms of the 1,5-cyclization of an acyl-substituted nitrile ylide intermediate, and the formation of the pyrrole derivatives is explained by the 1,3-dipolar cycloaddition of the same intermediate with DMAD.The regiochemistry of the cycloaddition of the acyl-substituted nitrile ylide with methyl propiolate showed that the contribution of an allenyl-type resonance structure plays an important role in the acyl-substituted nitrile ylide reaction.

Formation and Reaction of Acyl Substituted Nitrile Ylide through the Rh2(OAc)4-Catalyzed Reaction of α-Diazocarbonyl Compounds with Benzonitrile

The rhodium(II) acetate-catalyzed reaction of α-diazocarbonyl compounds with benzonitrile and dimethyl acetylenedicarboxylate gave oxazoles and pyrrole-3,4-dicarboxylates through the 1,5-cyclization and 1,3-dipolar cycloaddition of the acyl substituted nitrile ylide intermediates generated by the reaction of ketocarbenoids with benzonitrile.