2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate

Base Information

• Chemical Name: 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate
• CAS No.: 1374003-13-0
• Molecular Formula: C₁₁H₉Cl₃N₂O₄
• Molecular Weight: 339.562
• Mol file: 1374003-13-0.mol

Synonyms:2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate

Chemical Property of 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate

There total 2 articles about 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-nitrostyrene (100-13-0) + 2,2,2,-trichloroethoxycarbonyl azide → 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate (1374003-13-0)

Guidance literature:

With Co(3,5-di^tBu-QingPhyrin); potassium carbonate; In chlorobenzene; at -20 ℃; for 48h; enantioselective reaction; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1016/j.chempr.2021.03.001

Reference yield:

O-tosyl-N-trichloroethoxycarbonylhydroxylamine (931109-52-3) + 4-nitrostyrene (100-13-0) → C11H9Cl3N2O4 (1374003-08-3) + 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate (1374003-13-0)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; (4R,4'R)-2,2'-(propane-2,2-diyl)bis(5,5-dimethyl-4-phenyl-4,5-dihydrooxazole); potassium carbonate; In acetonitrile; at 23 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.tet.2012.02.044

Reference yield: 100.0%

methanol (67-56-1) + 2,2,2-trichloroethyl 2-(4-nitrophenyl)aziridine-1-carboxylate (1374003-13-0) → 2,2,2-trichloroethyl 2-methoxy-2-(4-nitrophenyl)ethylcarbamate

Guidance literature:

With boron trifluoride diethyl etherate; at 20 ℃; for 1h; stereospecific reaction; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.chempr.2021.03.001

upstream raw materials:

O-tosyl-N-trichloroethoxycarbonylhydroxylamine

4-nitrostyrene

Downstream raw materials:

(R)-2-(4-nitrophenyl)aziridine