8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine
• CAS No.: 901124-80-9
• Molecular Formula: C₂₀H₂₃IN₄O
• Molecular Weight: 462.333
• Mol file: 901124-80-9.mol

Synonyms:8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

Chemical Property of 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

There total 2 articles about 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(chloromethyl)-8-iodo-6-methylimidazo[1,2-a]pyridine (901124-76-3) + 1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) → 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine (901124-80-9)

Guidance literature:

With sodium carbonate; In ethanol; for 3h; Heating;

DOI:10.1021/jm060166w

Reference yield:

2-amino-3-iodo-5-methylpyridine (211308-79-1) → 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine (901124-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / 1,2-dimethoxy-ethane / 20 °C

2: 81 percent / Na₂CO₃ / ethanol / 3 h / Heating

With sodium carbonate; In 1,2-dimethoxyethane; ethanol;

DOI:10.1021/jm060166w

Reference yield: 72.0%

morpholine (110-91-8,99108-56-2) + 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine (901124-80-9) → 2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-8-morpholin-4-yl-imidazo[1,2-a]pyridine

Guidance literature:

With potassium phosphate; copper(l) iodide; In ethylene glycol; isopropyl alcohol; at 85 ℃; for 48h;

DOI:10.1021/jm060166w

upstream raw materials:

2-(chloromethyl)-8-iodo-6-methylimidazo[1,2-a]pyridine

1-(2-methoxyphenyl)piperazine hydrochloride

2-amino-3-iodo-5-methylpyridine