2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde

Base Information

• Chemical Name: 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde
• CAS No.: 173276-66-9
• Molecular Formula: C₁₃H₁₂O₃S
• Molecular Weight: 248.302
• Mol file: 173276-66-9.mol

Synonyms:2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde

Chemical Property of 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde

There total 1 articles about 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-thiophene carboxaldehyde (498-62-4) + 4-methoxy-benzaldehyde (123-11-5) → 2-<1-hydroxy-(3-thienyl)methyl>thiophene-3-carbaldehyde (173276-64-7) + 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde (173276-66-9)

Guidance literature:

With samarium; 1,2-Diiodoethane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 0 - 20 ℃; for 2h;

DOI:10.1021/jo980851d

Reference yield: 92.0%

N-phenyl-maleimide (941-69-5) + 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde (173276-66-9) → 8-(4-methoxy-phenyl)-6-phenyl-1-thia-6-aza-s-indacene-5,7-dione

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; for 2h; Heating;

DOI:10.1021/jo980851d

Reference yield: 92.0%

dimethyl acetylenedicarboxylate (762-42-5) + 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-thiophene-3-carbaldehyde (173276-66-9) → 4-hydroxy-7-(4-methoxy-phenyl)-benzo[b]thiophene-5,6-dicarboxylic acid dimethyl ester

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; for 2h; Heating;

DOI:10.1021/jo980851d

upstream raw materials:

3-thiophene carboxaldehyde

4-methoxy-benzaldehyde

Downstream raw materials:

3-((Z)-2-Benzylsulfanyl-vinyl)-5-(4-methoxy-phenyl)-2,5-dihydro-furan-2-ol

2-(4-methoxy-benzoyl)-thiophene-3-carbaldehyde