methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate

Base Information

• Chemical Name: methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate
• CAS No.: 858133-22-9
• Molecular Formula: C₁₇H₁₉NO₄
• Molecular Weight: 301.342
• Mol file: 858133-22-9.mol

Synonyms:methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate

Chemical Property of methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate

There total 2 articles about methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-acetyl-2-ethylpent-4-ynoic acid phenylamide (858133-23-0) + methanol (67-56-1) + carbon monoxide (201230-82-2) → methyl (E)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate + methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate (858133-22-9)

Guidance literature:

With oxygen; potassium iodide; palladium(II) iodide; In acetonitrile; under 24001.9 Torr;

DOI:10.1021/jo050155v

Reference yield:

2-ethyl-3-oxo-N-phenylbutanamide (31844-89-0) → methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate (858133-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / K₂CO₃ / toluene; acetone / 15 h / Heating

2: 83 percent / PdI₂; KI; O₂ / acetonitrile / 24001.9 Torr

With oxygen; potassium carbonate; potassium iodide; palladium(II) iodide; In acetone; toluene; acetonitrile;

DOI:10.1021/jo050155v

Reference yield: 95.0%

methyl (Z)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate (858133-22-9) → methyl (E)-(4-acetyl-4-ethyl-5-oxo-1-phenylpyrrolidin-2-ylidene)acetate

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 0.333333h;

DOI:10.1021/jo050155v

upstream raw materials:

2-acetyl-2-ethylpent-4-ynoic acid phenylamide

methanol

carbon monoxide

2-ethyl-3-oxo-N-phenylbutanamide