2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

Base Information

Chemical Name:2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide
CAS No.:1362818-86-7
Molecular Formula:C₂₉H₂₆F₂N₄O₄
Molecular Weight:532.547
Hs Code.:

Synonyms:2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

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Chemical Property of 2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

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Technology Process of 2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

There total 11 articles about 2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1362820-01-6
2-((4-fluorobenzyl)oxy)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzoic acid

: 1362818-86-7
2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362818-86-7
2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / 24 h / 50 °C

2.1: bromine / chloroform / 1 h / 0 °C

3.1: pyridine / 4 h

4.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

5.1: water; calcium carbonate / 1,4-dioxane / 3 h / 150 °C

6.1: potassium carbonate / N,N-dimethyl-formamide

7.1: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

8.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h

9.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.42 h / 130 °C / Sealed vial

10.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 80 °C

10.2: pH 2

11.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With pyridine; sodium chlorite; potassium phosphate; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; potassium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 4670-56-8
methyl 2-hydroxy-4-methylbenzoate

: 1362818-86-7
2-((4-fluorobenzyl)oxy)-N-(3-fluorophenyl)-5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholine-4-carbonyl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: bromine / chloroform / 1 h / 0 °C

2.1: pyridine / 4 h

3.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

4.1: water; calcium carbonate / 1,4-dioxane / 3 h / 150 °C

5.1: potassium carbonate / N,N-dimethyl-formamide

6.1: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

7.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h

8.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.42 h / 130 °C / Sealed vial

9.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 80 °C

9.2: pH 2

10.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With pyridine; sodium chlorite; potassium phosphate; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; potassium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;