11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

Base Information

Chemical Name:11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one
CAS No.:98214-72-3
Molecular Formula:C₃₄H₄₂N₂O₆
Molecular Weight:574.717
Hs Code.:

Synonyms:11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

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Chemical Property of 11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

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Technology Process of 11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

There total 3 articles about 11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

: 123-62-6
propionic acid anhydride

: 98214-71-2
11β,21-dihydroxy-17α-propanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

: 98214-72-3
11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

Guidance literature:: With triethylamine; In dichloromethane; for 5h;
DOI:10.1248/cpb.34.1613

Reference yield:

: 98214-73-4
11β,17α,21-trihydroxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

: 98214-72-3
11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / p-toluenesulfonic acid / dimethylformamide / 1 h / 70 - 80 °C

2: 62.3 percent / 2 N aq. oxalic acid / methanol / 0.17 h / 40 °C

3: 83.7 percent / Et₃N / CH₂Cl₂ / 5 h

With oxalic acid; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1613

Reference yield:

: 103549-70-8
11β,17α,21-trihydroxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one 17,21-ethyl orthopropanoate

: 98214-72-3
11β-hydroxy-17α,21-dipropanoyloxy-2'-phenyl-2'H-2,4-pregnadieno<3,2-c>pyrazol-20-one

Guidance literature:: Multi-step reaction with 2 steps

1: 62.3 percent / 2 N aq. oxalic acid / methanol / 0.17 h / 40 °C

2: 83.7 percent / Et₃N / CH₂Cl₂ / 5 h

With oxalic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1248/cpb.34.1613