(+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide

Base Information

• Chemical Name: (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide
• CAS No.: 911805-41-9
• Molecular Formula: C₁₉H₂₀O₅
• Molecular Weight: 328.365
• Mol file: 911805-41-9.mol

Synonyms:(+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide

Chemical Property of (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide

There total 7 articles about (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(hydroxy-4 methoxy-3 benzyl)-4 dihydro-3H-furannone-2 (84755-40-8) → (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide (911805-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂; pyridine / 1.33 h / Ambient temperature

2: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

3: CH₂Cl₂; diethyl ether / 48 h / Ambient temperature

With N-Bromosuccinimide; Perbenzoic acid; In pyridine; tetrachloromethane; diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)99363-8

Reference yield:

(+/-)-3-(4-Trimethylsiloxy-3-methoxybenzyl)butan-4-olide (127951-00-2) → (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide (911805-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

2: CH₂Cl₂; diethyl ether / 48 h / Ambient temperature

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)99363-8

Reference yield:

3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid (111194-04-8) → (+/-)-3-(α-Benzyloxy-4-hydroxy-3-methoxybenzyl)butan-4-olide (911805-41-9)

Guidance literature:

Multi-step reaction with 4 steps

1: calcium borohydride

2: CH₂Cl₂; pyridine / 1.33 h / Ambient temperature

3: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

4: CH₂Cl₂; diethyl ether / 48 h / Ambient temperature

With N-Bromosuccinimide; Perbenzoic acid; calcium borohydride; In pyridine; tetrachloromethane; diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(00)99363-8

upstream raw materials:

(+/-)-3-<α-Bromo-4-(tertio-butyl dimethylsiloxy)-3-methoxybenzyl>butan-4-olide

benzyl alcohol

(hydroxy-4 methoxy-3 benzyl)-4 dihydro-3H-furannone-2

(+/-)-3-(4-Trimethylsiloxy-3-methoxybenzyl)butan-4-olide

Downstream raw materials:

(+/-)-3-(α-Benzyloxy-4-trimethylsiloxy-3-methoxybenzyl)butan-4-olide

(+/-)-α-conidendrin

4-[Benzyloxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-3-(4-hydroxy-3-methoxy-benzyl)-dihydro-furan-2-one

4-[Benzyloxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-3-(4-benzyloxy-3-methoxy-benzyl)-dihydro-furan-2-one