(4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

Base Information

Chemical Name:(4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone
CAS No.:1384177-47-2
Molecular Formula:C₂₁H₁₈N₂O₃
Molecular Weight:346.386
Hs Code.:

Synonyms:(4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

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Technology Process of (4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

There total 3 articles about (4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1097-25-2
(4‐methoxyphenyl)[4‐(4‐methoxyphenyl)‐1H‐imidazol‐2‐yl]methanone

: 106-96-7
propargyl bromide

: 1384177-47-2
(4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

Guidance literature:: (4‐methoxyphenyl)[4‐(4‐methoxyphenyl)‐1H‐imidazol‐2‐yl]methanone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

propargyl bromide; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1002/hc.21412

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1384177-47-2
(4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: selenium(IV) oxide / 1,4-dioxane / 0.05 h / 120 °C / Microwave irradiation

1.2: 0.5 h

2.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 1 h / 20 °C

With selenium(IV) oxide; tetrabutylammomium bromide; sodium hydroxide; In 1,4-dioxane; water; toluene;
DOI:10.1055/s-0031-1290979

Reference yield:

: 1076-95-5
p-methoxyphenylglyoxal

: 1384177-47-2
(4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / 1,4-dioxane; ethanol / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 0 °C

With ammonium acetate; sodium hydride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2018.06.033