(6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Name:(6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.:1489080-54-7
Molecular Formula:C₂₃H₂₂N₄O₈S₂
Molecular Weight:546.582
Hs Code.:

Synonyms:(6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Property of (6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Technology Process of (6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 3 articles about (6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 957-68-6
7-Aminocephalosporanic acid

: 203640-35-1
4-[(anilinocarbonyl)amino]benzenesulfonyl chloride

: 1489080-54-7
(6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: 7-Aminocephalosporanic acid; With potassium carbonate; In water; acetone; at -5 ℃; for 0.166667h;

4-[(anilinocarbonyl)amino]benzenesulfonyl chloride; In water; acetone; at -5 - 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2013.07.040

Reference yield:

: 24939-24-0
4-aminobenzenesulfonyl chloride

: 1489080-54-7
(6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 13 h / Reflux

2.1: potassium carbonate / water; acetone / 0.17 h / -5 °C

2.2: 24 h / -5 - 20 °C

With potassium carbonate; In ethanol; water; acetone;
DOI:10.1016/j.ejmech.2013.07.040

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1489080-54-7
(6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrazine hydrate / ethanol / 0.33 h / 100 °C / Microwave irradiation

2.1: ethanol / 13 h / Reflux

3.1: potassium carbonate / water; acetone / 0.17 h / -5 °C

3.2: 24 h / -5 - 20 °C

With palladium on activated charcoal; potassium carbonate; hydrazine hydrate; In ethanol; water; acetone;
DOI:10.1016/j.ejmech.2013.07.040