Technology Process of 2-[(4-cyanobenzyl)oxy]-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid
There total 7 articles about 2-[(4-cyanobenzyl)oxy]-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / H2 / Pd/C / ethanol / 20 °C
2: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
3: 83 percent / aq. NaHCO3 / 1 h / Heating
4: 17 percent / K2CO3 / acetone / 40 °C
5: 38 percent / potassium fluoride / dimethylformamide / 20 - 60 °C
6: 69 percent / aq. NaOH / ethanol / 20 °C
With
potassium fluoride; sodium hydroxide; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
diethyl ether; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm048984g
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / sulphuric acid / 2 h / Heating
2: 100 percent / H2 / Pd/C / ethanol / 20 °C
3: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
4: 83 percent / aq. NaHCO3 / 1 h / Heating
5: 17 percent / K2CO3 / acetone / 40 °C
6: 38 percent / potassium fluoride / dimethylformamide / 20 - 60 °C
7: 69 percent / aq. NaOH / ethanol / 20 °C
With
potassium fluoride; sodium hydroxide; sulfuric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
diethyl ether; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm048984g