2-hydroxymethyl-5-methoxy furan

Base Information

• Chemical Name: 2-hydroxymethyl-5-methoxy furan
• CAS No.: 87091-05-2
• Molecular Formula: C₆H₈O₃
• Molecular Weight: 128.128
• Mol file: 87091-05-2.mol

Synonyms:2-hydroxymethyl-5-methoxy furan

Chemical Property of 2-hydroxymethyl-5-methoxy furan

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-hydroxymethyl-5-methoxy furan

There total 1 articles about 2-hydroxymethyl-5-methoxy furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-(3aR,4R,7R,7aS)-4-(hydroxymethyl)-7-methoxy-2-(4-methoxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione → 2-hydroxymethyl-5-methoxy furan (87091-05-2) + N-(4-methoxyphenyl)maleimide (1081-17-0)

Guidance literature:

at 70 ℃; Kinetics;

DOI:10.1021/acs.joc.8b00135

Reference yield: 69.0%

2-hydroxymethyl-5-methoxy furan (87091-05-2) → 5-methoxyfuran-2-carbaldehyde (21300-07-2)

Guidance literature:

With manganese(IV) oxide; In ethanol; dichloromethane; for 16h; Ambient temperature;

Reference yield: 60.0%

2-hydroxymethyl-5-methoxy furan (87091-05-2) + 1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) → 2-benzyl-4-(hydroxymethyl)-7-methoxyisoindoline-1,3-dione

Guidance literature:

2-hydroxymethyl-5-methoxy furan; 1-benzyl-1H-pyrrole-2,5-dione; In acetonitrile; at 40 - 50 ℃; for 22h; Inert atmosphere;

In acetonitrile; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.joc.8b00135

Downstream raw materials:

5-methoxyfuran-2-carbaldehyde

2-(2-(5-methoxy)furanyl)-3-phenyl-1-pivaloylindoline

1-(2-(5-methoxy)furanyl)-2-phenyl-2-(2-pivaloylamododiphenyl)ethanol