2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine

Base Information

• Chemical Name: 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine
• CAS No.: 102676-41-5
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.315
• Mol file: 102676-41-5.mol

Synonyms:2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine

Chemical Property of 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine

There total 5 articles about 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

formic acid (64-18-6) + 6-(aminomethyl)-2-<4-(ethoxycarbonyl)phenyl>pyridine (102676-40-4) → 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine (102676-41-5)

Guidance literature:

at 90 ℃; for 15h;

DOI:10.1021/jm00106a038

Reference yield:

ethyl 4-(2-pyridinyl)benzoate (4385-61-9) → 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine (102676-41-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 40percent peracetic acid / 3 h / 90 °C

2: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

3: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

4: 83 percent / 15 h / 90 °C

With hydrogenchloride; peracetic acid; hydrogen; dimethyl sulfate; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00106a038

Reference yield:

2-<4-(ethoxycarbonyl)phenyl>pyridine N-oxide (102676-38-0) → 2-<4-(ethoxycarbonyl)phenyl>-6-<(formylamino)methyl>pyridine (102676-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

2: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

3: 83 percent / 15 h / 90 °C

With hydrogenchloride; hydrogen; dimethyl sulfate; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00106a038

upstream raw materials:

formic acid

6-(aminomethyl)-2-<4-(ethoxycarbonyl)phenyl>pyridine

ethyl 4-(2-pyridinyl)benzoate

2-<4-(ethoxycarbonyl)phenyl>pyridine N-oxide

Downstream raw materials:

5-(4-carboxyphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine

5-(4-carbamylphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine

fadrozole

5-<4-(ethoxycarbonyl)phenyl>-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine hydrochloride