methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Base Information

Chemical Name:methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate
CAS No.:895795-22-9
Molecular Formula:C₂₂H₁₆ClNO₃S
Molecular Weight:409.893
Hs Code.:

Synonyms:methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

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Chemical Property of methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

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Technology Process of methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

There total 8 articles about methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 897771-13-0
methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 895795-22-9
methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Guidance literature:: methyl 11-oxo-10,11-dihydrodibenzo[b,f][1,4]-thiazepine-8-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at -20 - 5 ℃; Inert atmosphere;

1-bromomethyl-3-chlorobenzene; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 19.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.028

Reference yield:

: 440627-10-1
3-amino-4-(2-carboxy-phenylsulfanyl)-benzoic acid

: 895795-22-9
methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 29 h / -20 - 20 °C

2.1: dmap / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / -20 - 5 °C / Inert atmosphere

3.2: 19.5 h / -20 - 20 °C / Inert atmosphere

With dmap; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.028

Reference yield:

: 1319194-13-2
methyl 4-((2-(methoxycarbonyl) phenyl) thio)-3-nitrobenzoate

: 895795-22-9
methyl 10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on carbon; platinum(IV) oxide; hydrogen / methanol; ethyl acetate / 12 h

2.1: lithium hydroxide / tetrahydrofuran; water / 37 h / 0 - 20 °C

2.2: pH 4

3.1: N,N-dimethyl-formamide / 29 h / -20 - 20 °C

4.1: dmap / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / -20 - 5 °C / Inert atmosphere

5.2: 19.5 h / -20 - 20 °C / Inert atmosphere

With dmap; platinum(IV) oxide; palladium on carbon; hydrogen; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.028