N-(3-fluorobenzyl)pyrrolidine

Base Information

• Chemical Name: N-(3-fluorobenzyl)pyrrolidine
• CAS No.: 784181-89-1
• Molecular Formula: C₁₁H₁₄FN
• Molecular Weight: 179.237
• Mol file: 784181-89-1.mol

Synonyms:N-(3-fluorobenzyl)pyrrolidine

Chemical Property of N-(3-fluorobenzyl)pyrrolidine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluorobenzyl)pyrrolidine

There total 1 articles about N-(3-fluorobenzyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

pyrrolidine (123-75-1) + 3-Fluorobenzaldehyde (456-48-4) → N-(3-fluorobenzyl)pyrrolidine (784181-89-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.04.077

Reference yield: 60.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + N-(3-fluorobenzyl)pyrrolidine (784181-89-1) → ethyl 1-(3-fluorobenzyl)-4,5-dihydro-1H-pyrrole-3-carboxylate

Guidance literature:

With copper diacetate; potassium iodide; palladium dichloride; In acetonitrile; at 80 ℃; for 12h; Schlenk technique;

DOI:10.1039/c6cc10227a

Reference yield:

N-(3-fluorobenzyl)pyrrolidine (784181-89-1) → ethyl 1-(4-chlorobenzyl)-1H-pyrrole-3-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: palladium dichloride; copper diacetate; potassium iodide / acetonitrile / 12 h / 80 °C / Schlenk technique

2: oxygen / dimethyl sulfoxide / 12 h / 80 °C / Schlenk technique; Sealed tube

With oxygen; copper diacetate; potassium iodide; palladium dichloride; In dimethyl sulfoxide; acetonitrile;

DOI:10.1039/c6cc10227a

upstream raw materials:

pyrrolidine

3-Fluorobenzaldehyde