methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

Base Information

Chemical Name:methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate
CAS No.:960391-38-2
Molecular Formula:C₂₇H₃₇F₂N₃O₃
Molecular Weight:489.606
Hs Code.:

Synonyms:methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

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Chemical Property of methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

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Technology Process of methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

There total 9 articles about methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 960391-21-3
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylic acid

: 81270-37-3
methyl piperidine-4-acetate hydrochloride

: 960391-38-2
methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 809273-65-2
(4,4-difluorocyclohexane)methylamine hydrochloride

: 960391-38-2
methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 75 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

3.1: dmap / dichloromethane / 4 h / 20 °C

4.1: acetic acid / 3 h / 150 °C / Microwave irradiation

5.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

5.2: pH 5 - 6

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With dmap; lithium hydroxide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 809273-66-3
methyl {[(4,4-difluorocyclohexyl)methanol]amino}-3-nitrobenzoate

: 960391-38-2
methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

2.1: dmap / dichloromethane / 4 h / 20 °C

3.1: acetic acid / 3 h / 150 °C / Microwave irradiation

4.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

4.2: pH 5 - 6

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With dmap; lithium hydroxide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;