8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol

Base Information

• Chemical Name: 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol
• CAS No.: 199010-68-9
• Molecular Formula: C₂₃H₃₄N₂O₆SSi
• Molecular Weight: 494.684
• Mol file: 199010-68-9.mol

Synonyms:8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol

Chemical Property of 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol

There total 3 articles about 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

cyclohexanedione monoethylene ketal (4746-97-8) + 2-Benzenesulfonyl-4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole (199010-64-5) → 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol (199010-68-9)

Guidance literature:

With tert-butylmagnesium bromide; In dichloromethane; at 0 ℃;

DOI:10.1016/S0040-4039(97)10128-9

Reference yield:

2-(phenylthio)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole (153172-35-1) → 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol (199010-68-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / MCPBA, Na₃HPO₄ / methanol / 22 °C

2: 82 percent / n-BuLi, N-iodosuccinimide / tetrahydrofuran / -78 °C

3: 75 percent / t-BuMgBr / CH₂Cl₂ / 0 °C

With N-iodo-succinimide; n-butyllithium; Na₃HPO₄; tert-butylmagnesium bromide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0040-4039(97)10128-9

Reference yield:

2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole (199010-63-4) → 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol (199010-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / n-BuLi, N-iodosuccinimide / tetrahydrofuran / -78 °C

2: 75 percent / t-BuMgBr / CH₂Cl₂ / 0 °C

With N-iodo-succinimide; n-butyllithium; tert-butylmagnesium bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(97)10128-9

upstream raw materials:

cyclohexanedione monoethylene ketal

2-Benzenesulfonyl-4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

2-(phenylthio)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole