199010-63-4

Upstream product

• 153172-35-1 2-(phenylthio)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole 

Downstream Products

• 199010-64-5 2-Benzenesulfonyl-4-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole 
• 199010-68-9 8-[2-Benzenesulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-1,4-dioxa-spiro[4.5]decan-8-ol 
• 307304-81-0 5-(1,1-dibutyl-1-stannapentyl)-1-[(3,3-dimethyl-3-silabutoxy)methyl]-2-(phenylsulfonyl)imidazole 

Relevant academic research and scientific papers

1-[2'-(trimethylsilyl)ethoxymethyl]-2-phenylsulfonylimidazole: A new reagent for the preparation of C-4 substituted imidazoles

The title compound provides for the efficient C-4 metallation of the imidazole nucleus. Further reactions lead to trisubstituted imidazoles which can be selectively deprotected at the N1 and C2 positions under mild conditions to maximize the potential for further elaboration.

Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith

Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.