8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide

Base Information

Chemical Name:8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide
CAS No.:59468-83-6
Molecular Formula:C18H13ClFN3O
Molecular Weight:341.772
Hs Code.:
UNII:SP3M57VEE5
DSSTox Substance ID:DTXSID00574276
Mol file:59468-83-6.mol

Synonyms:59468-83-6;Midazolam 5-Oxide;Midazolam oxide;SP3M57VEE5;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide;UNII-SP3M57VEE5;Midazolam impurity D [EP];4H-Imidazo(1,5-a)(1,4)benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, 5-oxide;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine 5-oxide;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide (Midazolam 5-Oxide);(Midazolam 5-Oxide);SCHEMBL7309545;DTXSID00574276;FIDBLKWFRFIVLJ-UHFFFAOYSA-N;AKOS030242504;MIDAZOLAM IMPURITY D [EP IMPURITY];8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-5-oxide;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide (Midazolam 5-Oxide) (1mg/ml in Acetonitrile);8-Chloro-6-(2-fluorophenyl)-1-methyl-5-oxo-4H-5lambda~5~-imidazo[1,5-a][1,4]benzodiazepine

Suppliers and Price of 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide

Chemical Property:

Melting Point:233°C dec.
Boiling Point:572.0±60.0 °C(Predicted)
PKA:4.29±0.40(Predicted)
PSA：46.57000
Density:1.40±0.1 g/cm3(Predicted)
LogP:3.79330
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:341.0731179
Heavy Atom Count:24
Complexity:517

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=[N+](C2)[O-])C4=CC=CC=C4F
Uses An intermediate in the synthesis of CYP3A4, a metabolite of midazolam A metabolite of Midazolam (M343000).

Technology Process of 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide

There total 6 articles about 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: