(1R^*,2S^*,4R^*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol

Base Information

• Chemical Name: (1R^*,2S^*,4R^*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol
• CAS No.: 125032-06-6
• Molecular Formula: C₂₂H₂₉NO₄
• Molecular Weight: 371.477

Synonyms:(1R^*,2S^*,4R^*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol

Chemical Property of (1R^*,2S^*,4R^*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol

Chemical Property:

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Technology Process of (1R^*,2S^*,4R^*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol

There total 7 articles about (1R^*,2S^*,4R^*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(1R*,2S*,4R*)-4-(benzyloxy)-2-bromo-1-(3,4-dimethoxyphenyl)cyclohexan-1-ol (125032-05-5) + methylamine (74-89-5) → (1R*,2S*,4R*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol (125032-06-6)

Guidance literature:

In methanol; at 100 ℃; for 7h;

DOI:10.1021/jo00001a021

Reference yield: 83.0%

(1R,2R,4S)-4-Benzyloxy-2-bromo-1-(3,4-dimethoxy-phenyl)-cyclohexanol + methylamine (74-89-5) → (1R*,2S*,4R*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol (125032-06-6)

Guidance literature:

In methanol; at 100 ℃; in a sealed tube;

DOI:10.1039/c39890000762

Reference yield: 78.0%

(1R*,2S*,4R*)-4-(benzyloxy)-1,2-epoxy-1-(3,4-dimethoxyphenyl)cyclohexane (129920-37-2) + methylamine (74-89-5) → (1R*,2S*,4R*)-4-(benzyloxy)-1-(3,4-dimethoxyphenyl)-2-(methylamino)cyclohexan-1-ol (125032-06-6)

Guidance literature:

In methanol; at 100 ℃; for 7h;

DOI:10.1021/jo00001a021

upstream raw materials:

(1R^*,2S^*,4R^*)-4-(benzyloxy)-1,2-epoxy-1-(3,4-dimethoxyphenyl)cyclohexane

methylamine

(1R^*,2S^*,4R^*)-4-(benzyloxy)-2-bromo-1-(3,4-dimethoxyphenyl)cyclohexan-1-ol

4-(benzyloxy)-1-(3,4-dimethoxyphenyl)cyclohex-1-ene

Downstream raw materials:

(3aR^*,6R^*,7aS^*)-6-(benzyloxy)octahydro-3a-(3,4-dimethoxyphenyl)-1-methylindole

(3aR^*,6R^*,7aS^*)-6-(benzyloxy)octahydro-3a-(3,4-dimethoxyphenyl)-1-methylindol-2-one

(1S^*,5R^*)-N-<5-(benzyloxy)-2-(3,4-dimethoxyphenyl)cyclohex-2-en-1-yl>-N-methylacetamide

N-<5-(benzyloxy)-2-(3,4-dimethoxyphenyl)cyclohex-1-en-1-yl>-α,α-dichloro-N-methylacetamide

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