2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester

Base Information

• Chemical Name: 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester
• CAS No.: 1327310-60-0
• Molecular Formula: C₁₄H₁₄BrFO₄
• Molecular Weight: 345.165
• Mol file: 1327310-60-0.mol

Synonyms:2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester

Chemical Property of 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester

There total 2 articles about 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-bromo-2-(4-fluorophenyl)acetic acid (29270-33-5) + (R)-Pantolacton (599-04-2) → 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester (1327310-60-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h;

Reference yield: 86.0%

2-bromo-2-(4-fluorophenyl)acetic acid (29270-33-5) + (S)-pantolactone (79-50-5,599-04-2,5405-40-3,52126-90-6) → 2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester (1327310-60-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h;

Reference yield:

2-bromo-2-(4-fluorophenyl)acetic acid (R)-pantolactone ester (1327310-60-0) + N,N'-Dibenzylethylenediamine (140-28-3,87170-83-0) → 1,4-dibenzyl-(R)-3-(4-fluorophenyl)-2-piperazinone + 1,4-dibenzyl-(S)-3-(4-fluorophenyl)-2-piperazinone (1327310-72-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; optical yield given as %ee; stereoselective reaction;

DOI:10.1016/j.tet.2011.06.055

upstream raw materials:

2-bromo-2-(4-fluorophenyl)acetic acid

(R)-Pantolacton

(S)-pantolactone

Downstream raw materials:

1,4-dibenzyl-(S)-3-(4-fluorophenyl)-2-piperazinone

2S-(4-fluorophenyl)-piperazine