2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane

Base Information

• Chemical Name: 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane
• CAS No.: 97579-93-6
• Molecular Formula: C₁₅H₁₈INO₄
• Molecular Weight: 403.217
• Mol file: 97579-93-6.mol

Synonyms:2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane

Chemical Property of 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane

There total 5 articles about 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(Allyl-phenoxycarbonyl-amino)-2-bromo-propionic acid ethyl ester (97579-89-0) → 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane (97579-93-6)

Guidance literature:

With potassium iodide; 18-crown-6 ether; In acetone;

DOI:10.1016/S0040-4020(01)86134-2

Reference yield: 27.0%

3-(Allyl-phenoxycarbonyl-amino)-2-bromo-propionic acid ethyl ester (97579-89-0) → 4-Iodomethyl-pyrrolidine-1,3-dicarboxylic acid 3-ethyl ester 1-phenyl ester (97579-97-0) + 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane (97579-93-6)

Guidance literature:

With potassium iodide; In butanone; for 2h; Heating;

DOI:10.3987/COM-89-5305

Reference yield:

ethyl 3-(prop-2-en-1-ylamino)propanoate (44981-87-5) → 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane (97579-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / K₂CO₃ / acetone / 1 h

2: 1.) LDA, Me₃SiCl, 2.) Br₂ / 1.) THF, -78 deg C, 40 min, 50 min, 2.) THF, pentane, 10 min

3: 93 percent / KI / 18-crown-6 / acetone

With chloro-trimethyl-silane; bromine; potassium carbonate; potassium iodide; lithium diisopropyl amide; 18-crown-6 ether; In acetone;

DOI:10.1016/S0040-4020(01)86134-2

upstream raw materials:

3-(Allyl-phenoxycarbonyl-amino)-2-bromo-propionic acid ethyl ester

ethyl 3-(prop-2-en-1-ylamino)propanoate

2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonylethane

phenyl chloroformate

Downstream raw materials:

4-Iodomethyl-pyrrolidine-1,3-dicarboxylic acid 3-ethyl ester 1-phenyl ester

3-ethoxycarbonyl-4-iodomethyl-1-phenoxycarbonylpyrrolidine

3-ethoxycarbonyl-4-iodomethyl-1-phenoxycarbonylpyrrolidine