4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

Base Information

Chemical Name:4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide
CAS No.:1581275-52-6
Molecular Formula:C₂₅H₂₂ClN₃O
Molecular Weight:415.922
Hs Code.:

Synonyms:4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

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Chemical Property of 4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

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Technology Process of 4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

There total 5 articles about 4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1581275-71-9
4-(2-chlorophenyl)-N-(4-methylbenzyl)quinazoline-2-carboxamide

: 75-03-6
ethyl iodide

: 1581275-52-6
4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm401721h

Reference yield:

: 1373887-64-9
4-(2-chlorophenyl)quinazoline-2-carboxylic acid

: 1581275-52-6
4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 2 h / Reflux; Inert atmosphere

2: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 25 °C / Inert atmosphere

With thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm401721h

Reference yield:

: 1373887-67-2
C₁₅H₁₁ClN₂O₂

: 1581275-52-6
4-(2-chlorophenyl)-N-ethyl-N-(4-methylbenzyl)quinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 12 h / 20 °C / Irradiation

2: thionyl chloride / 2 h / Reflux; Inert atmosphere

3: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 25 °C / Inert atmosphere

With thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm401721h