2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide

Base Information

Chemical Name:2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide
CAS No.:1416057-72-1
Molecular Formula:C₂₄H₁₆N₂O₄S₂
Molecular Weight:460.534
Hs Code.:

Synonyms:2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide

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Chemical Property of 2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide

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Technology Process of 2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide

There total 2 articles about 2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1416057-99-2
3-phenoxy-5-(phenylsulfanyl)pyridine 1-oxide

: 81-07-2
saccharin

: 1416057-73-2
C₂₄H₁₆N₂O₄S₂

: 1416057-72-1
2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide

Guidance literature:: 3-phenoxy-5-(phenylsulfanyl)pyridine 1-oxide; saccharin; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃;

With p-toluenesulfonyl chloride; In dichloromethane; at 0 - 5 ℃; for 2h; regioselective reaction;
DOI:10.1021/ol303218p

Reference yield:

: 2402-99-5
3,5-dibromopyridine-N-oxide

: 108-98-5
thiophenol

: 108-95-2,27073-41-2
phenol

: 1416057-73-2
C₂₄H₁₆N₂O₄S₂

: 1416057-72-1
2-[3-phenoxy-5-(phenylsulfanyl)pyridin-2-yl]-1,2-benzothiazol-3(2H)-one 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / dimethyl sulfoxide / 16 h / 90 °C / Inert atmosphere

1.2: 7 h / 90 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C

2.2: 2 h / 0 - 5 °C

With potassium phosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol303218p