4-(Morpholine-4-Carbonyl)-Benzaldehyde

Base Information

• Chemical Name: 4-(Morpholine-4-Carbonyl)-Benzaldehyde
• CAS No.: 58287-80-2
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.24
• Hs Code.: 2934999090
• Mol file: 58287-80-2.mol

Synonyms:4-(Morpholine-4-Carbonyl)-Benzaldehyde

Chemical Property of 4-(Morpholine-4-Carbonyl)-Benzaldehyde

Chemical Property:

• PSA: 46.61000
• LogP: 0.90940

Purity/Quality:

98% ^*data from raw suppliers

4-(Morpholine-4-carbonyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Morpholine-4-Carbonyl)-Benzaldehyde

There total 7 articles about 4-(Morpholine-4-Carbonyl)-Benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

morpholine (110-91-8,99108-56-2) + dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + 4-bromo-benzaldehyde (1122-91-4) → 4-[(morpholin-4-yl)carbonyl]benzaldehyde (58287-80-2)

Guidance literature:

With dmap; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.062

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + carbon monoxide (201230-82-2) + 4-bromo-benzaldehyde (1122-91-4) → 4-[(morpholin-4-yl)carbonyl]benzaldehyde (58287-80-2)

Guidance literature:

With potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 105 ℃; for 12h; under 3000.3 Torr;

DOI:10.1021/cs400232b

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + 4-Carboxybenzaldehyde (619-66-9) → 4-[(morpholin-4-yl)carbonyl]benzaldehyde (58287-80-2)

Guidance literature:

4-Carboxybenzaldehyde; With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃;

morpholine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2011.10.061

upstream raw materials:

morpholine

4-Carboxybenzaldehyde

(4-bromophenyl)(morpholino)methanone

9-methyl-9H-fluorene-9-carbonyl chloride

Downstream raw materials:

(4-(di(1H-pyrrol-2-yl)methyl)phenyl)(morpholino)methanone

5,5'-((4-(morpholine-4-carbonyl)phenyl)methylene)bis(1H-pyrrole-2-carbaldehyde)

(E)-2-cyano-N-cyclopropyl-3-[4-(morpholin-4-ylcarbonyl)phenyl]acrylamide

C₂₈H₂₉N₃O₆

Refernces

• 1、 -. "PROTEIN-PROTEIN INTERACTION STABILIZERS". Paragraph 0041; 1043-1044; 1046. . Retrieved 2021/10/11.
• 2、 -. "COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF". Paragraph 0266-0267. . Retrieved 2020/07/07.