C₂₃H₄₁NO₃Si

Base Information

• Chemical Name: C₂₃H₄₁NO₃Si
• CAS No.: 1191041-40-3
• Molecular Formula: C₂₃H₄₁NO₃Si
• Molecular Weight: 407.669
• Mol file: 1191041-40-3.mol

Synonyms:C₂₃H₄₁NO₃Si

Chemical Property of C₂₃H₄₁NO₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₄₁NO₃Si

There total 4 articles about C₂₃H₄₁NO₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

(2R)-(tert-butyldimethyl)-(3-iodo-2-methylpropoxy)silane (105859-46-9) + N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide (159213-03-3) → C23H41NO3Si (1191041-40-3)

Guidance literature:

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

(2R)-(tert-butyldimethyl)-(3-iodo-2-methylpropoxy)silane; In tetrahydrofuran; hexane; at 0 - 20 ℃;

DOI:10.1021/ja9060596

Reference yield:

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate (105859-44-7) → C23H41NO3Si (1191041-40-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane; methanol / 1.33 h / -78 - -42 °C

2.1: 1H-imidazole; triphenylphosphine / dichloromethane / 0 °C

2.2: 1.08 h / 0 - 20 °C

3.1: tetrahydrofuran / -78 °C

3.2: 1.5 h / -78 - 0 °C

3.3: 1 h / -78 - 20 °C

With 1H-imidazole; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ja404134f

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → C23H41NO3Si (1191041-40-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

2.1: diisobutylaluminium hydride / dichloromethane; methanol / 1.33 h / -78 - -42 °C

3.1: 1H-imidazole; triphenylphosphine / dichloromethane / 0 °C

3.2: 1.08 h / 0 - 20 °C

4.1: tetrahydrofuran / -78 °C

4.2: 1.5 h / -78 - 0 °C

4.3: 1 h / -78 - 20 °C

With 1H-imidazole; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ja404134f

upstream raw materials:

(2R)-(tert-butyldimethyl)-(3-iodo-2-methylpropoxy)silane

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate

tert-butyldimethylsilyl chloride

Downstream raw materials:

acetyl narbonolide

10-deoxymethynolide