1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

Base Information

Chemical Name:1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone
CAS No.:110567-19-6
Molecular Formula:C₂₈H₄₃N₃O₉Si₂
Molecular Weight:621.835
Hs Code.:

Synonyms:1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

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Chemical Property of 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

There total 6 articles about 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 108782-90-7
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone

: 74-88-4
methyl iodide

: 110567-19-6
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

Guidance literature:: With silver(l) oxide; In acetone; at 20 ℃; for 72h;

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 110567-19-6
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 20 °C

2: triethylamine / CH₂Cl₂ / 0.25 h / 20 °C

3: 1.) triethylamine, 2-mesitylenesulfonyl chloride, N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo<2.2.2>octane / 1.) dichloromethane, 30 min, 2.) dichloromethane, 60 min

4: 1.12 g / p-toluenesulfonic acid / CH₂Cl₂ / 0.03 h / 20 °C

5: 81 percent / silver oxide / acetone / 72 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; 2-mesitylenesulphonyl chloride; toluene-4-sulfonic acid; triethylamine; silver(l) oxide; In dichloromethane; acetone;

Reference yield:

: 4-(2-Nitro-phenoxy)-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one

: 110567-19-6
1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.12 g / p-toluenesulfonic acid / CH₂Cl₂ / 0.03 h / 20 °C

2: 81 percent / silver oxide / acetone / 72 h / 20 °C

With toluene-4-sulfonic acid; silver(l) oxide; In dichloromethane; acetone;