N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester

Base Information

• Chemical Name: N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester
• CAS No.: 220079-41-4
• Molecular Formula: C₁₉H₂₃N₃O₅S
• Molecular Weight: 405.475
• Mol file: 220079-41-4.mol

Synonyms:N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester

Chemical Property of N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester

There total 3 articles about N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Tosyl isocyanate (4083-64-1) + N'-Ethyl-N-methyl-hydrazinecarboxylic acid benzyl ester (220079-16-3) → N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester (220079-41-4)

Guidance literature:

In dichloromethane;

DOI:10.1055/s-1998-2217

Reference yield:

1-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)carbonyl]-2-methylhydrazine (127799-53-5) → N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester (220079-41-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃, Bu₄NHSO₄, NaOH / benzene / 30 h / Ambient temperature

2: TFA / CH₂Cl₂ / 2 h

3: 99 percent / CH₂Cl₂

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; trifluoroacetic acid; In dichloromethane; benzene;

DOI:10.1055/s-1998-2217

Reference yield:

1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine (220079-14-1) → N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester (220079-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 2 h

2: 99 percent / CH₂Cl₂

With trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-1998-2217

upstream raw materials:

Tosyl isocyanate

N'-Ethyl-N-methyl-hydrazinecarboxylic acid benzyl ester

1-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)carbonyl]-2-methylhydrazine

1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine

Downstream raw materials:

1-ethyl-2-methyl-2-(tosylcarbamoyl)-1-[(trideuteromethyl)tosylcarbamoyl]hydrazine

C₁₂H₁₆⁽²⁾H₃N₃O₃S

1-(benzyloxycarbonyl)-2-ethyl-1-methyl-2-[(trideuteromethyl)tosylcarbamoyl]hydrazine